Adaptogens have long been associated with increasing energy, enhancing stamina, and reducing mild fatigue. They encourage physical work capacity and mental performance. Often referred to as tonics, they have far reaching effects on overall physiological health, supporting immune, cardiovascular, and endocrine functions. At the same time, they help the body to adapt to and cope with occasional stress, primarily by supporting the hypothalamic-pituitary-adrenal (HPA) axis. Panax ginseng promotes endurance and stamina, while also promoting cognitive, cardiovascular and immune function. Ashwagandha is recognized for supporting immune function and cognitive function. Rhodiola and eleuthero are traditionally associated with rejuvenating effects and the ability to promote endurance.